NUCC-390 (hydrochloride)

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Cat No: 30957

Biochemicals - Receptor Pharmacology

NUCC-390 is a chemokine (C-X-C motif) receptor 4 (CXCR4) agonist.{61069} It induces calcium mobilization in C8161 melanoma cells expressing CXCR4 when used at a concentration of 10 µM, an effect that can be prevented by the CXCR4 antagonist AMD3100 (p...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-piperidinyl[4,5,6,7-tetrahydro-1-propyl-5-[[2-(4-pyridinyl)ethyl]amino]-1H-indazol-3-yl]-methanone, dihydrochloride

Correlated keywords:

1060524-97-1 Oxyuranus NUCC390 CXC C 8161 CXCR 4 AMD 3100 neuro paralysis

Product Overview:
NUCC-390 is a chemokine (C-X-C motif) receptor 4 (CXCR4) agonist.{61069} It induces calcium mobilization in C8161 melanoma cells expressing CXCR4 when used at a concentration of 10 µM, an effect that can be prevented by the CXCR4 antagonist AMD3100 (plerixafor; Item No. 10011332). NUCC-390 (0.0625, 0.125, and 0.25 µM) increases axon length in cultured rat spinal cord motor neurons.{61071} In vivo, NUCC-390 (26 mg/kg per day) restores gastrocnemius muscle compound muscle action potentials (CMAPs) in a mouse model of sciatic nerve crush injury. It also restores CMAPs in a mouse model of neuroparalysis induced by Papuan taipan (O. scutellatus) venom.{61070}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₂₃H₃₃N₅O • 2HCl
SMILES	CCCN1N=C(C(N2CCCCC2)=O)C3=C1CCC(C3)NCCC4=CC=NC=C4.Cl.Cl
Molecular Weight	468,5
Formulation	A solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.