Ergosterol Peroxide

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Ergosterol Peroxide

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Cat No: 30860

Ergosterol peroxide is an oxidized sterol and derivative of ergosterol (Item No. 19850) that has been found in S. aspratus and has diverse biological activities.{59102,59103,59104,59105,59106} It is active against the P. falciparum chloroquine-sensiti...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,5?,8?,22E)-5,8-epidioxy-ergosta-6,22-dien-3-ol

Correlated keywords:

22321-17-1 49759-24-2 64907-19-3 122406-63-7 132008-50-5 256942-55-9 2044999-96-2 2131091-11-5 2135874-28-9 2170259-78-4 DU 145 FCA20 NFkB NSC31324 Plasmodium Sarcodon SNU1 SNU354 SNUC4 TNF?

Product Overview:
Ergosterol peroxide is an oxidized sterol and derivative of ergosterol (Item No. 19850) that has been found in S. aspratus and has diverse biological activities.{59102,59103,59104,59105,59106} It is active against the P. falciparum chloroquine-sensitive strain FCA 20/GHA with an IC50 value of 8.2 µM.{59103} Ergosterol peroxide (6.25-50 µM) induces apoptosis in LNCaP and DU145 prostate cancer cells.{59104} It inhibits growth of SNU-1 gastric, SNU-354 hepatoma, and SNU-C4 colorectal cancer cells (IC50s = 18.7, 158.2, and 84.6 µM, respectively).{59107} Ergosterol peroxide (60 µM) inhibits LPS-induced NF-kB DNA-binding activity and production of TNF-α in RAW 264.7 cells.{59105} Topical application of ergosterol peroxide reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) with an ID50 value of 0.2 mg/ear.{59106}

Size	500 µg
Shipping	dry ice
CAS Number	2061-64-5
Molecular Formula	C₂₈H₄₄O₃
SMILES	CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@@]3(OO4)C=C[C@@]54C[C@@H](O)CC[C@]5(C)[C@@]3([H])CC[C@@]21C
Molecular Weight	428,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2906.13
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.