Ethosuximide-d5

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Ethosuximide-d₅

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Cat No: 30759

Biochemicals - Isotopically Labeled Standards

Ethosuximide-d5 is intended for use as an internal standard for the quantification of ethosuximide (Item No. 23947) by GC- or LC-MS. Ethosuximide is an anticonvulsant.{36303,36304,36305,36306,36307} It increases glucose, fructose-1,6-bisphosphate, and...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(ethyl-1,1,2,2,2-d5)-3-methyl-2,5-pyrrolidinedione

Correlated keywords:

CI366-d5 CI366d5 NSC64013-d5 NSC64013d5 deuterated deuterium GCMS LCMS

Product Overview:
Ethosuximide-d5 is intended for use as an internal standard for the quantification of ethosuximide (Item No. 23947) by GC- or LC-MS. Ethosuximide is an anticonvulsant.{36303,36304,36305,36306,36307} It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg.{36303} Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions.{36304} It also inhibits tonic hindlimb extension induced by pentylenetetrazole (PTZ; Item No. 18682) or brainstem stimulation (ED50s = 35 and 70 mg/kg, respectively), as well as leptazol-induced clonic seizures (ED50 = 230 mg/kg), in rats.{36305,36306} Ethosuximide reduces resting tremor by 60% in a macaque model of Parkinson's disease induced by MPTP when administered at a dose of 150 mg/animal for 5 days.{36307} Formulations containing ethosuximide have been used in the treatment of petit mal seizures.

Size	1 mg
Shipping	dry ice
CAS Number	1989660-59-4
Molecular Formula	C₇H₆D₅NO₂
SMILES	O=C1CC(C([2H])([2H])C([2H])([2H])[2H])(C)C(N1)=O
Molecular Weight	146,2
Formulation	A solid
Purity	≥99% deuterated forms (d1-d5)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.