Tormentic Acid

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Tormentic Acid

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Cat No: 30696

Biochemicals - Natural Products

Tormentic acid is a triterpene that has been found in P. frutescens and has diverse biological activities, including anti-inflammatory, anticancer, antioxidative, and antidiabetic properties.{42870,49711,49712} It reduces hydrogen peroxide-induced inc...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2?,3?)-2,3,19-trihydroxy-urs-12-en-28-oic acid

Correlated keywords:

11008-23-4 Perilla antiinflammatory anti cancer oxidative diabetic NOX 1 TNF? IL6 IL1?

Product Overview:
Tormentic acid is a triterpene that has been found in P. frutescens and has diverse biological activities, including anti-inflammatory, anticancer, antioxidative, and antidiabetic properties.{42870,49711,49712} It reduces hydrogen peroxide-induced increases in inducible nitric oxide synthase (iNOS) and NADPH oxidase (NOX1), as well as the production of TNF-α, IL-6, and IL-1β in rat vascular smooth muscle cells (RVSMCs) when used at concentrations of 12.5, 25, and 50 µM.{49711} Tormentic acid (25 and 50 µM) decreases hydrogen peroxide-induced generation of reactive oxygen species (ROS) in RVSMCs. It reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice (ID50 = 0.03 mg/ear).{42870} Topical application of tormentic acid (1.7 nmol) reduces the number of papillomas formed per mouse in a DMBA-TPA two-stage model of mouse skin carcinogenesis. It also reduces increases in blood glucose, insulin, and leptin levels, as well as hepatic triglyceride levels, in mice fed a high-fat diet in a model of diabetes and hyperlipidemia when administered at doses of 60 and 120 mg/kg per day.{49712}

Size	1 mg
Shipping	dry ice
CAS Number	13850-16-3
Molecular Formula	C₃₀H₄₈O₅
SMILES	CC1(C)[C@@H](O)[C@H](O)C[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@](O)(C)[C@H](C)CC[C@]5(C(O)=O)CC[C@@]4(C)[C@]3(C)CC[C@]21[H]
Molecular Weight	488,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2918.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.