Arenobufagin

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Arenobufagin

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Cat No: 30695

Biochemicals - Lipids

Arenobufagin is a cardiotonic steroid that has been found in the skin secretions of the toad B. gargarizans and has anticancer activity.{52655,52656,42766,52657} It inhibits Na+/K+-ATPase activity in isolated guinea pig ventricular myocytes with an IC...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,5?,11?)-3,11,14-trihydroxy-12-oxo-bufa-20,22-dienolide

Correlated keywords:

anti-cancer Bufo Hep-G2 HepG-2 Hep-3B Hep3-B BEL7402 MCF7 PC-3

Product Overview:
Arenobufagin is a cardiotonic steroid that has been found in the skin secretions of the toad B. gargarizans and has anticancer activity.{52655,52656,42766,52657} It inhibits Na+/K+-ATPase activity in isolated guinea pig ventricular myocytes with an IC50 value of 290 nM.{52655} Arenobufagin (20-500 nM) induces cleavage of poly(ADP-ribose) polymerase (PARP), caspase-3, and caspase-9, as well as induces apoptosis in HepG2 hepatocellular carcinoma cells.{52656} It inhibits proliferation of HepG2, Hep3B, BEL-7402, and MCF-7 cancer cells (IC50s = 101.9, 39.8, 416.3, and 143.7 nM, respectively), as well as multidrug-resistant HepG2/adm and MCF-7/adr cancer cells (IC50s = 730 and 67.5 nM, respectively). Arenobufagin (1 mg/kg once per day, i.v.) reduces tumor growth, the number and size of lung metastases, and tumor levels of the epithelial-to-mesenchymal transition (EMT) markers vimentin and β-catenin in a PC3 mouse xenograft model.{42766} Arenobufagin (5 and 10 µM/plug) inhibits VEGF-induced angiogenesis in a Matrigel™ plug assay in mice.{52657}

Size	1 mg
Shipping	dry ice
CAS Number	464-74-4
Molecular Formula	C₂₄H₃₂O₆
SMILES	O[C@H]1CC[C@@]2(C)[C@@](CC[C@]([C@]3(O)[C@@]4(C)[C@](C5=COC(C=C5)=O)([H])CC3)([H])[C@]2([H])[C@H](O)C4=O)([H])C1
Molecular Weight	416,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2932.20
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.