BKT 140

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BKT 140

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Cat No: 30689

Biochemicals - Receptor Pharmacology

BKT 140 is an antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4; IC50 = 0.91 nM).{54472} It inhibits HIV-1-induced cytopathogenicity in MT-4 cells with an EC50 value of 4 nM. BKT 140 (100 nM) reduces migration of SUP-T1 leukemia and MDA-MB-231 b...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N2-(4-fluorobenzoyl)-L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-L-argininamide, cyclic (4?13)-disulfide

Correlated keywords:

BKT140 CXCR NB 4 HIV1 MT4 SUPT1 MDAMB231 CXC CXCL 12 RPMI8226 TN 14016 TN 14003 BL8040

Product Overview:
BKT 140 is an antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4; IC50 = 0.91 nM).{54472} It inhibits HIV-1-induced cytopathogenicity in MT-4 cells with an EC50 value of 4 nM. BKT 140 (100 nM) reduces migration of SUP-T1 leukemia and MDA-MB-231 breast cancer cells induced by chemokine (C-X-C) ligand 12 (CXCL12).{54472} It induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells when used at concentrations 8 and 40 µM.{54473} BKT 140 reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model.{54472} It also reduces the incidence of arthritis in a mouse model of collagen-induced arthritis.{54474}

Size	500 µg
Shipping	dry ice
CAS Number	664334-36-5
Molecular Formula	C₉₇H₁₄₄FN₃₃O₁₉S₂
SMILES	NCCCC[C@@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C2=CC=C(C=C2)F)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CSSC[C@@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@]5([H])CCCN5C([C@H](NC1=O)CCCCN
Molecular Weight	2159,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.