Tenuifolin

Confirm delete?

Tenuifolin

Zoom

Cat No: 30617

Biochemicals - Natural Products

Tenuifolin is a saponin that has been found in P. tenuifolia and has neuroprotective activity.{56157,56158} It inhibits β-secretase (BACE) activity by 54.4% when used at a concentration of 10 μg/ml.{56158} Tenuifolin (2 μg/ml) inhibits secretion of am...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(4?)-3?-(?-D-glucopyranosyloxy)-2?,27-dihydroxy-olean-12-ene-23,28-dioic acid

Correlated keywords:

Polygala neuro protective A? 40 A? 42 COS7 APP 695 APP695WT 695WT APP695Swe PC 12

Product Overview:
Tenuifolin is a saponin that has been found in P. tenuifolia and has neuroprotective activity.{56157,56158} It inhibits β-secretase (BACE) activity by 54.4% when used at a concentration of 10 μg/ml.{56158} Tenuifolin (2 μg/ml) inhibits secretion of amyloid-β (1-40) (Aβ40) and Aβ42 from COS-7 cells expressing wild-type amyloid precursor protein isoform 695 (APP695 WT) or Swedish mutant APP695 (APP695 Swe). It prevents decreases in PC12 cell viability induced by Aβ (25-35) when used at concentrations of 20 and 40 μg/L.{56157} Tenuifolin (3 and 9 mg/kg) inhibits increases in the escape latency and total swimming distance induced by Aβ (25-35) in the Morris water maze in mice.

Size	1 mg
Shipping	dry ice
CAS Number	20183-47-5
Molecular Formula	C₃₆H₅₆O₁₂
SMILES	CC1(C)CC[C@@]2(C(O)=O)[C@@](C3=CC[C@@]([C@](C[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@]5(C)C(O)=O)(C)[C@@]5([H])CC6)([H])[C@]6(C)[C@]3(CO)CC2)([H])C1
Molecular Weight	680,8
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2938.90
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.