Onjisaponin B

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Onjisaponin B

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Cat No: 30521

Biochemicals - Natural Products

Onjisaponin B is a triterpenoid saponin that has been found in P. tenuifolia and has neuroprotective activity.{49643,49644,49645} It inhibits glutamate- or serum-starvation-induced neurotoxicity in PC12 cells when used at a concentration of 10 μM.{496...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2?,3?,4?)-3-(?-D-glucopyranosyloxy)-2,27-dihydroxy-olean-12-ene-23,28-dioic acid, 28-[O-6-deoxy-?-L-mannopyranosyl-(1?3)-O-[O-?-D-galactopyranosyl-(1?4)-O-?-D-xylopyranosyl-(1?4)-6-deoxy-?-L-mannopyranosyl-(1?2)]-6-deoxy-4-O-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-?-D-galactopyranosyl] ester

Correlated keywords:

11076-97-4 71875-83-7 343249-07-0 Sinezin 3 paeonia neuro toxicity PC 12 HEK 293 PS 1 IL1? IL6 TNF?

Product Overview:
Onjisaponin B is a triterpenoid saponin that has been found in P. tenuifolia and has neuroprotective activity.{49643,49644,49645} It inhibits glutamate- or serum-starvation-induced neurotoxicity in PC12 cells when used at a concentration of 10 μM.{49643} Onjisaponin B decreases amyloid-β production in HEK293/APPswe cells (IC50 = 10 μM).{49644} It reduces spatial learning and memory deficits in the Morris water maze in an APP/PS1 transgenic mouse model of Alzheimer's disease when administered at a dose of 10 mg/kg per day. Onjisaponin B (10 and 20 mg/kg) prevents D-galactose-induced decreases in hippocampal glutathione (GSH) levels and increases in hippocampal malondialdehyde (MDA), IL-1β, IL-6, and TNF-α levels in a rat model of D-galactose-induced aging.{49645}

Size	1 mg
Shipping	dry ice
CAS Number	35906-36-6
Molecular Formula	C₇₅H₁₁₂O₃₅
SMILES	OC[C@H]1O[C@@H](O[C@@H]2[C@](C(O)=O)(C)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(CO)CC[C@]6(C(O[C@@H]7O[C@H](C)[C@H](OC(/C=C/C8=CC=C(OC)C=C8)=O)[C@H](O[C@@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O)[C@H]7O[C@@H]%10O[C@@H](C)[C@H](O[C@@H]%11OC[C@@H](O[C@H]%12[C@H](
Molecular Weight	1573,7
Formulation	A solid
Purity	≥95%
Custom Code	2938.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.