Halicin

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Halicin

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Cat No: 30436

Biochemicals - Kinase Inhibitors

Halicin is a JNK1 inhibitor (IC50 = 0.7 µM).{58266,58267} It is selective for JNK1 over p38α, Furin, and lethal factor (IC50s = >100, >100, and >50 µM, respectively), as well as Akt at 100 µM.{58266} Halicin inhibits TNF-α-induced phosphorylation of c...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-[(5-nitro-2-thiazolyl)thio]-1,3,4-thiadiazol-2-amine

Correlated keywords:

JNK 1 TNF? Clostridium Pseudomonas Acinetobacter

Product Overview:
Halicin is a JNK1 inhibitor (IC50 = 0.7 µM).{58266,58267} It is selective for JNK1 over p38α, Furin, and lethal factor (IC50s = >100, >100, and >50 µM, respectively), as well as Akt at 100 µM.{58266} Halicin inhibits TNF-α-induced phosphorylation of c-Jun in a cell-based assay (EC50 = 6.23 µM). In vivo, halicin (25 mg/kg) reduces blood glucose levels and restores insulin sensitivity in insulin insensitive mice. Halicin is active against carbapenem-resistant Enterobacteriaceae (MICs = 1-10 µg/ml), as well as multidrug-resistant A. baumannii and P. aeruginosa (MICs = 1-10 and 1-100 µg/ml, respectively).{58267} It reduces the number of wound tissue colony forming units (CFUs) in a mouse model of A. baumannii wound infection. Halicin (15 mg/kg) also reduces fecal bacterial load in a mouse model of C. difficile infection.

Size	5 mg
Shipping	dry ice
CAS Number	40045-50-9
Molecular Formula	C₅H₃N₅O₂S₃
SMILES	NC1=NN=C(SC2=NC=C([N+]([O-])=O)S2)S1
Molecular Weight	261,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2934.10
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.