Piribedil

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Piribedil

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Cat No: 30321

Biochemicals - Receptor Pharmacology

Piribedil is a dopamine receptor agonist.{56138,56139,56140,56141} It binds to dopamine D2, D3, and D4 receptors (IC50s = 1-1,000 nM in radioligand binding assays).{56138} Piribedil (1 and 10 mg/kg) enhances spontaneous object recognition in young adu...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-pyrimidine

Correlated keywords:

1451048-94-4 D 2 3 4 6OHDA LDOPA ET 495 ET495 EU 4200 EU4200 Pronoran

Product Overview:
Piribedil is a dopamine receptor agonist.{56138,56139,56140,56141} It binds to dopamine D2, D3, and D4 receptors (IC50s = 1-1,000 nM in radioligand binding assays).{56138} Piribedil (1 and 10 mg/kg) enhances spontaneous object recognition in young adult rats and attenuates age-related memory impairments in the radial arm maze in mice.{56139} It reduces immobility time in the forced swim test in mice when administered at doses ranging from 0.63 to 10 mg/kg.{56140} Piribedil (0.3 mg/kg) decreases the number of premature and delayed responses in a response time test, indicating improved attentional function, in a rat model of Parkinson's disease induced by 6-OHDA (Item No. 25330) when administered in combination with L-DOPA (Item No. 13248).{56141}

Size	100 mg
Shipping	dry ice
CAS Number	04/01/3605 00:00
Molecular Formula	C₁₆H₁₈N₄O₂
SMILES	N1(C2=NC=CC=N2)CCN(CC3=CC(OCO4)=C4C=C3)CC1
Molecular Weight	298,3
Formulation	A solid
Purity	≥98%
Custom Code	2934.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.