Pulchinenoside B4

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Pulchinenoside B₄

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Cat No: 30271

Biochemicals - Natural Products

Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities.{48998,48999} It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in supe...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,4?)-3-[[2-O-(6-deoxy-?-L-mannopyranosyl)-?-L-arabinopyranosyl]oxy]-23-hydroxy-lup-20(29)-en-28-oic acid, O-6-deoxy-?-L-mannopyranosyl-(1?4)-O-?-D-glucopyranosyl-(1?6)-?-D-glucopyranosyl ester

Correlated keywords:

1310041-11-2 B 4 Pulsatilla HEK 293 lipopolysaccharide TNF? IL6 IL1? Chinensioside A saponin

Product Overview:
Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities.{48998,48999} It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM.{48998} Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner.{48999} Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.

Size	5 mg
Shipping	dry ice
CAS Number	129741-57-7
Molecular Formula	C₅₉H₉₆O₂₆
SMILES	CC([C@@H]1CC[C@]2(C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]4O[C@H](CO)[C@@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@H](O)[C@H]4O)O3)=O)CC[C@@]6(C)[C@]7(C)CC[C@@]8([H])[C@](C)(CO)[C@@H](O[C@H]9[C@H](O[C@H]%10[C@H](O)[C@H](O)[C@@H](O)[C@H](C)
Molecular Weight	1221,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2938.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.