Lapachol

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Lapachol

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Cat No: 30190

Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities.{53616,53618,53617,53619,53620} It is larvicidal against T. canis when used at a concentration of 2 mg/ml.{53616} Lapachol (10 and 100 µM) inhi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-hydroxy-3-(3-methyl-2-buten-1-yl)-1,4-naphthalenedione

Correlated keywords:

Tabebuia Toxocara Bothrops PLA-2 CI75490 CI-75490 Bethabarra Surinam Greenheart Ipe-tobacco Taigu Wood Natural Yellow 16 NSC11905 NSC629756 Taiguic acid Tecomin

Product Overview:
Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities.{53616,53618,53617,53619,53620} It is larvicidal against T. canis when used at a concentration of 2 mg/ml.{53616} Lapachol (10 and 100 µM) inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells.{53618} It reduces B. atrox venom phospholipase A2 (PLA2) activity in a turbidimetric assay when used at a concentration of 10 µg/ml.{53617} Lapachol (3 and 10 mg/kg) reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis.{53619} It also reduces carrageenan-induced paw edema and abscess formation in rats.{53620}

Size	100 mg
Shipping	dry ice
CAS Number	84-79-7
Molecular Formula	C₁₅H₁₄O₃
SMILES	O=C1C(C/C=C(C)/C)=C(O)C(C2=CC=CC=C21)=O
Molecular Weight	242,3
Formulation	A solid
Purity	≥95%
Custom Code	2914.79
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.