DNA Monoclonal Antibody (Clone 4

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DNA Monoclonal Antibody (Clone 4E9)

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Cat No: 30185

Activated neutrophils produce neutrophil extracellular traps (NETs), antimicrobial snares that are comprised of granular and cytoplasmic proteins, as well as decondensed nuclear DNA associated with histone proteins.{53539} NET degradation is impaired ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

ds-DNA NZBWF-1 mAb nonimmunized NZB/W F1 anti-microbial

Product Overview:
Activated neutrophils produce neutrophil extracellular traps (NETs), antimicrobial snares that are comprised of granular and cytoplasmic proteins, as well as decondensed nuclear DNA associated with histone proteins.{53539} NET degradation is impaired in patients with systemic lupus erythematosus (SLE), allowing for production of autoantibodies against NET components, including dsDNA. The NZBWF1 mouse model of SLE similarly produces autoantibodies against chromatin, dsDNA, and ssDNA.{53540,53541} Cayman's DNA Monoclonal Antibody (Clone 4E9) was developed by fusing the spleen of a non-immunized NZBWF1 mouse with a mouse myeloma cell line and can be used for immunohistochemistry (IHC), immunofluorescence (IF), and ELISA applications. The antibody recognizes ssDNA and dsDNA, including nuclear DNA, from human and bovine samples.

Size	100 µg
Shipping	dry ice
Host	Mouse
Clone	4000000000
Isotype	IgG1
Application(s)	IHC, IF, ELISA
Formulation	100 µg of protein G-purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.