Doxepin-13C-d3 (hydrochloride)

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Doxepin-¹³C-d₃ (hydrochloride)

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Cat No: 30121

Biochemicals - Isotopically Labeled Standards

Doxepin-13C-d3 is intended for use as an internal standard for the quantification of doxepin (Item No. 15888) by GC- or LC-MS. Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(E)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N-methyl-N-(methyl-13C-d3)propan-1-amine, monohydrochloride

Correlated keywords:

GCMS LCMS deuterated deuterium HCl tri cyclic anti depressant 5HT H 1 2 3 4 5HT2 ? ?1AR

Product Overview:
Doxepin-13C-d3 is intended for use as an internal standard for the quantification of doxepin (Item No. 15888) by GC- or LC-MS. Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET; Kds = 68 and 29.5 nM, respectively).{22877} It is a histamine H1 receptor antagonist (Ki = 1.23 nM).{40358} Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT; Kd = 12,100 nM) and inhibits histamine H1 over H2, H3, and H4 receptors (Kis = 170, 39,810, and 15,135 nM, respectively).{22877,40358} It also binds to the 5-HT2 receptor, as well as to muscarinic acetylcholine and α1-adrenergic receptors (α1-ARs; Kds = 27, 23, and 23.5 nM, respectively).{25803} Doxepin (10 mg/kg, i.p.) decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain.{48874} It increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress when administered orally at a dose of 15 mg/kg.{48875} Formulations containing doxepin have been used in the treatment of depression and insomnia.

Size	1 mg
Shipping	dry ice
Molecular Formula	C₁₈[¹³C]H₁₈D₃NO • HCl
SMILES	CN([13C]([2H])([2H])[2H])CC/C=C1C2=C(C=CC=C2)OCC3=C/1C=CC=C3.Cl
Molecular Weight	319,9
Formulation	A solid
Purity	≥99% deuterated forms (d1-d3)
Custom Code	3822.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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