Isocorydine

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Isocorydine

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Cat No: 30101

Biochemicals - Natural Products

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.{52447,52448,52449,52450,52451} It reduces the action potential duration and increases the effective refractory period in isolated ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(6aS)-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol

Correlated keywords:

11014-71-4 14028-99-0 Annona anti cancer Huh-7 Hep-G2 HepG-2 NSC32979 SNU449 SNU387

Product Overview:
Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.{52447,52448,52449,52450,52451} It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 µM.{52448} Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 µM.{52449} It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 µM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 µg/ml, respectively).{52450,52451} Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.{52451}

Size	5 mg
Shipping	dry ice
CAS Number	475-67-2
Molecular Formula	C₂₀H₂₃NO₄
SMILES	OC1=C2C(C[C@@]3([H])C(C2=C(OC)C(OC)=C4)=C4CCN3C)=CC=C1OC
Molecular Weight	341,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2939.79
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.