Polygalasaponin F

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Polygalasaponin F

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Cat No: 30064

Biochemicals - Natural Products

Polygalasaponin F is a triterpenoid saponin originally isolated from Polygala japonica and has diverse biological activities.{52413,52414,52415} It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, inducible nitric oxide syntha...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2?,3?,4?)-3-(?-D-glucopyranosyloxy)-2,23-dihydroxy-olean-12-en-28-oic acid, O-?-D-xylopyranosyl-(1?4)-O-6-deoxy-?-L-mannopyranosyl-(1?2)-?-D-glucopyranosyl ester

Correlated keywords:

BV2 KN93 MK801 NF?B tnf?

Product Overview:
Polygalasaponin F is a triterpenoid saponin originally isolated from Polygala japonica and has diverse biological activities.{52413,52414,52415} It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) levels, and nuclear translocation of NF-κB p65 in BV-2 microglia when used at concentrations of 0.1, 1, and 10 μM.{52413} Polygalasaponin F (0.1, 1, and 10 μM) inhibits rotenone-induced increases in intracellular reactive oxygen species (ROS) levels, decreases in mitochondrial membrane potential, and induction of apoptosis in PC12 cells.{52414} Intracerebroventricular administration of polygalasaponin F (1 and 10 μM) induces long-term potentiation in the hippocampal dentate gyrus in anesthetized rats, an effect that can be prevented by the NMDA receptor inhibitor MK-801 or the calcium/calmodulin-dependent protein kinase (CaMKII) inhibitor KN-93 (Item Nos. 13319
13864
21472).{52415}

Size	1 mg
Shipping	dry ice
CAS Number	882664-74-6
Molecular Formula	C₅₃H₈₆O₂₃
SMILES	OC[C@H]([C@@H](O)[C@H](O)[C@H]1O)O[C@H]1O[C@H]2[C@@H](O)C[C@]3(C)[C@@]4([H])CC=C5[C@]6([H])CC(C)(C)CC[C@]6(C(O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@H]8O[C@@H](C)[C@H](O[C@@H]9OC[C@@H](O)[C@H](O)[C@H]9O)[C@@H](O)[C@H]8O)=O)CC[C@@]5(C)[C@]4(C)CC[C@@]
Molecular Weight	1091,2
Formulation	A solid
Purity	≥95%
Custom Code	2938.90
UNSPSC code	12352100

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.