Fusidic Acid-d6

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Fusidic Acid-d₆

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Cat No: 29994

Biochemicals - Isotopically Labeled Standards

Fusidic acid-d6 is intended for use as an internal standard for the quantification of fusidic acid (Item No. 14825) by GC- or LC-MS. Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum.{54000} It is active against the Gram-posi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)-6-(methyl-d3)hept-5-enoic-7,7,7-d3 acid

Correlated keywords:

SQ 16,360 SQ16360 Fucidin Fucidina Fucidine Fusidin ZN 6-Na ZN6Na GCMS LCMS Deuturium deuterated anti-biotic Fusicoccin Staphylococcus Streptococcus Corynebacterium Bacillus Clostridium Escherichia Salmonella Proteus Candida Aspergillus TNF? IL6

Product Overview:
Fusidic acid-d6 is intended for use as an internal standard for the quantification of fusidic acid (Item No. 14825) by GC- or LC-MS. Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum.{54000} It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 µg/ml for all).{54001} Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively).{54002} Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.{54003}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₃₁H₄₂D₆O₆
SMILES	O[C@@H]1CC[C@@]2(C)[C@](CC[C@@]3(C)[C@@]2([H])[C@H](O)C[C@]4([H])[C@]3(C)C[C@H](OC(C)=O)/C4=C(C(O)=O)/CC/C=C(C([2H])([2H])[2H])/C([2H])([2H])[2H])([H])[C@@H]1C
Molecular Weight	522,8
Formulation	A solid
Purity	≥99% deuterated forms (d1-d6)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.