Diazoxide-d3

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Diazoxide-d₃

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Cat No: 29967

Biochemicals - Ion Channel Modulation

Diazoxide-d3 is intended for use as an internal standard for the quantification of diazoxide (Item No. 14576) by GC- or LC-MS. Diazoxide is an activator of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = 14.1 µM...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7-chloro-3-(methyl-d3)-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

Correlated keywords:

GCMS LCMS deuterated deuterium NSC64198 NSC 64198 76130 NSC76130 SRG 95213 SRG95213 HEK 293 293T T SUR Kir 6.2 K ir6.2 ir

Product Overview:
Diazoxide-d3 is intended for use as an internal standard for the quantification of diazoxide (Item No. 14576) by GC- or LC-MS. Diazoxide is an activator of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = 14.1 µM in a FLIPR assay using HEK293 cells).{36318} It also activates SUR2A/Kir6.2 and SUR2B/Kir6.2 channels in HEK293T cells in a patch-clamp assay when used at concentrations of 30 and 300 µM.{48765} Diazoxide inhibits glucose-induced insulin release from isolated rat pancreatic β cells and induces relaxation of isolated rat aortic rings precontracted with potassium chloride (IC50s = 22.6 and 22.4 µM, respectively).{48766} It reduces mean arterial pressure and cerebral blood flow in spontaneously hypertensive rats when administered intravenously as a 5 mg/kg bolus dose.{48767} Diazoxide (50 mg/kg, i.p.) increases blood glucose levels in mice.{48768} Formulations containing diazoxide have been used in the treatment of hypoglycemia.

Size	1 mg
Shipping	dry ice
CAS Number	1432063-51-8
Molecular Formula	C₈H₄ClD₃N₂O₂S
SMILES	ClC1=CC=C(NC(C([2H])([2H])[2H])=NS2(=O)=O)C2=C1
Molecular Weight	233,7
Formulation	A solid
Purity	≥99% deuterated forms (d1-d3)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.