Geraniin

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Geraniin

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Cat No: 29924

Biochemicals - Small Molecule Inhibitors

Geraniin is a tannin that has been found in P. urinaria and has diverse biological activities.{55054,48977,48978} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM),...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

cyclic 2?7:4?5-(3,6-dihydro-2,9,10,11,11-pentahydroxy-3-oxo-2,6-methano-2H-1-benzoxocin-5,7-dicarboxylate) cyclic 3,6-(4,4?,5,5?,6,6?-hexahydroxy[1,1?-biphenyl]-2,2?-dicarboxylate) 1-(3,4,5-trihydroxybenzoate), ?-D-glucopyranose, stereoisomer

Correlated keywords:

81856-90-8 Phyllanthus HSV1 HSV2 A 549 NSC359346

Product Overview:
Geraniin is a tannin that has been found in P. urinaria and has diverse biological activities.{55054,48977,48978} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM), and hydroxyl radicals (IC50 = 1.44 μM) in cell-free assays.{55054} Geraniin inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication in plaque reduction assays (IC50s = 35 and 18.4 μM, respectively).{48977} It inhibits angiotensin-converting enzyme (ACE) in vitro (IC50 = 13.22 μM) and reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg.{55054} Geraniin (5, 10, and 20 μM) induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells.{48978} It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 10 and 20 mg/kg.

Size	1 mg
Shipping	dry ice
CAS Number	60976-49-0
Molecular Formula	C₄₁H₂₈O₂₇
SMILES	OC1(C(C(C2=O)=CC3=O)C(C(OC13O)=C4O)=C(C=C4O)C(O[C@H](C5OC(C(C=C6O)=CC(O)=C6O)=O)[C@H](OC(C(C(C7=C8O)=C9O)=CC(O)=C9O)=O)[C@H]([C@H](COC(C7=CC(O)=C8O)=O)O5)O2)=O)O
Molecular Weight	952,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.