Nimbin

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Nimbin

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Cat No: 29884

Biochemicals - Natural Products

Nimbin is a limonoid that has been found in neem seeds and has diverse biological activities.{52347,52348,46670} It inhibits the growth of the plant pathogenic fungus D. oryzae by 64.8% when used at a concentration of 1,000 ppm.{52347} Nimbin (0.02-2,...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2R,3aR,4aS,5R,5aR,6R,9aR,10S,10aR)-5-(acetyloxy)-2-(3-furanyl)-3,3a,4a,5,5a,6,9,9a,10,10a-decahydro-6-(methoxycarbonyl)-1,6,9a,10a-tetramethyl-9-oxo-2H-cyclopenta[b]naphtho[2,3-d]furan-10-acetic acid, methyl ester

Correlated keywords:

22076-43-3 25990-69-6 Diaphorobacter Spodoptera

Product Overview:
Nimbin is a limonoid that has been found in neem seeds and has diverse biological activities.{52347,52348,46670} It inhibits the growth of the plant pathogenic fungus D. oryzae by 64.8% when used at a concentration of 1,000 ppm.{52347} Nimbin (0.02-2,000 μM) has antifeedant activity against S. littoralis in a choice test.{52348} It decreases melanin content to 20.9% of control, without affecting viability, in B16 murine melanoma cells when used at a concentration of 25 μg/ml.{46670} Nimbin inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells (IC50 = 499 mol ratio/32 pmol TPA).

Size	1 mg
Shipping	dry ice
CAS Number	5945-86-8
Molecular Formula	C₃₀H₃₆O₉
SMILES	CC1=C2[C@@]3(C)[C@H](CC(OC)=O)[C@@]4(C)C(C=C[C@](C(OC)=O)(C)[C@]4([H])[C@@H](OC(C)=O)[C@@]3([H])O[C@]2([H])C[C@@]1([H])C5=COC=C5)=O
Molecular Weight	540,6
Formulation	A solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.