8-Cyclopentyl-1,3-dimethylxanthi

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8-Cyclopentyl-1,3-dimethylxanthine

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Cat No: 29870

Biochemicals - Receptor Pharmacology

8-Cyclopentyl-1,3-dimethylxanthine (CPT) is an adenosine A1 receptor antagonist (Ki = 10.9 nM).{48947} It is selective for adenosine A1 over A2 receptors (Ki = 1,440 nM). CPT inhibits hypoxia-induced depression of evoked synaptic potentials in rat hip...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

8-cyclopentyl-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione

Correlated keywords:

A 1 2 NSC101806 Cyclopentyl theophylline PD 116600 PD116600

Product Overview:
8-Cyclopentyl-1,3-dimethylxanthine (CPT) is an adenosine A1 receptor antagonist (Ki = 10.9 nM).{48947} It is selective for adenosine A1 over A2 receptors (Ki = 1,440 nM). CPT inhibits hypoxia-induced depression of evoked synaptic potentials in rat hippocampal slices in a concentration-dependent manner.{48948} It increases secondary after-discharge duration in electrically induced seizures in rats when administered at doses of 2.5 mg/kg or higher.{48949} CPT increases the response rate under a fixed-interval schedule of stimulus-shock termination in squirrel monkeys (ED50 = 2.5 μmol/kg), indicating psychomotor stimulant effects.{48950}

Size	50 mg
Shipping	dry ice
CAS Number	35873-49-5
Molecular Formula	C₁₂H₁₆N₄O₂
SMILES	CN1C(N(C)C(N=C(C2CCCC2)N3)=C3C1=O)=O
Molecular Weight	248,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2934.99
UNSPSC code	12352100

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