Yatein

Yatein

CAT N°: 29766
Price:

From 231.00 196.35

Yatein is a lignan that has been found in C. formosana and has diverse biological activities.{46751,46752,46753,46754} It inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 1 ?M).{46751} Yatein inhibits herpes simplex virus 1 (HSV-1) replication in a plaque reduction assay (IC50 = 30.6 ?M).{46752} It induces apoptosis and production of reactive oxygen species (ROS) in, and is cytotoxic to, A549 and CL1-5 non-small cell lung cancer (NSCLC) cells (IC50s = 3.5 and 1.9 ?M, respectively).{46753} Yatein inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in a concentration-dependent manner.{46754}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-2(3H)-furanone
  • Correlated keywords
    • 153061-92-8 Dihydroanhydropodorhizol Deoxypodorhizon Calocedrus P 450 3A4 3A 4 3 A HSV1 A 549 CL 1-5 CL15 nonsmall cyto-toxic
  • Product Overview:
    Yatein is a lignan that has been found in C. formosana and has diverse biological activities.{46751,46752,46753,46754} It inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 1 ?M).{46751} Yatein inhibits herpes simplex virus 1 (HSV-1) replication in a plaque reduction assay (IC50 = 30.6 ?M).{46752} It induces apoptosis and production of reactive oxygen species (ROS) in, and is cytotoxic to, A549 and CL1-5 non-small cell lung cancer (NSCLC) cells (IC50s = 3.5 and 1.9 ?M, respectively).{46753} Yatein inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in a concentration-dependent manner.{46754}

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