Neridronic Acid

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Neridronic Acid

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Cat No: 29692

Biochemicals - Small Molecule Inhibitors

Neridronic acid is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 388.2 nM in a cell-free assay).{53519} It decreases the differentiation of RAW 264.7 cells into osteoclasts in a CRL-12257 co-culture model of osteo...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

P,P?-(6-amino-1-hydroxyhexylidene)bis-phosphonic acid

Correlated keywords:

437763-00-3 6-Amino-1-Hydroxy-Hexylidene-1,1-Bisphosphonate Nerixia CRL12257 osteo-clastogenesis FGF-2 HUVEC

Product Overview:
Neridronic acid is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 388.2 nM in a cell-free assay).{53519} It decreases the differentiation of RAW 264.7 cells into osteoclasts in a CRL-12257 co-culture model of osteoclastogenesis when used at concentrations ranging from 0.001 to 100 µM.{53520} Neridronic acid (30 µM) inhibits FGF2-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs).{53521} It reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats when administered subcutaneously at a dose of 0.1 mg/kg per day.{53522}

Size	5 mg
Shipping	dry ice
CAS Number	79778-41-9
Molecular Formula	C₆H₁₇NO₇P₂
SMILES	NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O
Molecular Weight	277,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2931.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.