Isorhyncho<wbr/>phylline

Isorhynchophylline

CAT N°: 29650
Price:

From 85.00 72.25

Isorhynchophylline is an oxindole alkaloid that has been found in Uncaria and has diverse biological activities, including neuroprotective, anticancer, and antihypertensive properties.{53326,53327,53328,53329} It inhibits decreases in cell viability and increases in intracellular levels of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by amyloid-? (25-35) (A? (25-35); Item No. 24155) in PC12 cells in a concentration-dependent manner.{53326} Isorhynchophylline (30 and 100 ?M) attenuates decreases in population spike amplitudes in the CA1 region of a rat hippocampal slice model of ischemia induced by oxygen and D-glucose deprivation.{53327} It decreases the viability of HepG2, A549, BxPC-3, Caki-1, RPMI-8226, and 786-O cells (IC50s = 130-292 ?M).{53328} In HepG2 cells, isorhynchophylline induces apoptosis, inhibits cell migration in a wound healing assay, and decreases invasion in a Matrigel™ assay. Isorhynchophylline (0.1% in the diet) decreases right ventricular end systolic pressure, hypertrophy, and fibrosis in a rat model of pulmonary arterial hypertension induced by monocrotaline (Item No. 16666).{53329}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (?E,1?S,6?R,7?S,8?aS)-6?-ethyl-1,2,2?,3?,6?,7?,8?,8?a-octahydro-?-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1?(5?H)-indolizine]-7?-acetic acid, methyl ester
  • Correlated keywords
    • Isoryncophylline anti-cancer hypertensive PC-12 CA-1 Hep-G2 A-549 BxPC3 Caki1 RPMI8226 786O
  • Product Overview:
    Isorhynchophylline is an oxindole alkaloid that has been found in Uncaria and has diverse biological activities, including neuroprotective, anticancer, and antihypertensive properties.{53326,53327,53328,53329} It inhibits decreases in cell viability and increases in intracellular levels of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by amyloid-? (25-35) (A? (25-35); Item No. 24155) in PC12 cells in a concentration-dependent manner.{53326} Isorhynchophylline (30 and 100 ?M) attenuates decreases in population spike amplitudes in the CA1 region of a rat hippocampal slice model of ischemia induced by oxygen and D-glucose deprivation.{53327} It decreases the viability of HepG2, A549, BxPC-3, Caki-1, RPMI-8226, and 786-O cells (IC50s = 130-292 ?M).{53328} In HepG2 cells, isorhynchophylline induces apoptosis, inhibits cell migration in a wound healing assay, and decreases invasion in a Matrigel™ assay. Isorhynchophylline (0.1% in the diet) decreases right ventricular end systolic pressure, hypertrophy, and fibrosis in a rat model of pulmonary arterial hypertension induced by monocrotaline (Item No. 16666).{53329}

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