Benserazide-d3 (hydrochloride)

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Benserazide-d₃ (hydrochloride)

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Cat No: 29643

Biochemicals - Isotopically Labeled Standards

Benserazide-d3 is intended for use as an internal standard for the quantification of benserazide (Item No. 20298) by GC- or LC-MS. Benserazide is a peripherally restricted inhibitor of aromatic L-amino acid decarboxylase (AADC; IC50 = 0.53 µM).{46663}...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide-2,3,3-d3, monohydrochloride

Correlated keywords:

deuterated deuterium GCMS LCMS Ro 4-4602 44602 Ro4 Ro44602 HCl HK 1 4 SW-480 si-RNA Lo Vo HCT 116 MCF7 SMMC7721 LDOPA 6OHDA

Product Overview:
Benserazide-d3 is intended for use as an internal standard for the quantification of benserazide (Item No. 20298) by GC- or LC-MS. Benserazide is a peripherally restricted inhibitor of aromatic L-amino acid decarboxylase (AADC; IC50 = 0.53 µM).{46663} It also inhibits tryptophan oxygenase and kynureninase (Kis = 41.8 and 26.4 µM, respectively, in rat liver homogenates), as well as hexokinase 2 (HK2), HK1, and HK4 (IC50s = 5.5, 25.1, and 40.5 µM, respectively, for the recombinant human enzymes).{46664,46665} Benserazide (50-400 µM) is cytotoxic to SW480 colorectal cancer cells, an effect that can be reversed by HK2 siRNA knockdown, and inhibits proliferation of SW480, LoVo, HCT116, MCF-7, and SMMC-7721 cancer cells with IC50 values of 143, 151, 181.4, 186, and 210.4 nM, respectively.{46665} It reduces tumor growth in an SW480 mouse xenograft model when administered at doses of 300 and 600 mg/kg per day for 16 days. Oral administration of benserazide (8.8 mg/kg) inhibits AADC activity in rat liver, kidney, and brain by approximately 90, 90, and 25%, respectively, and increases striatal dopamine levels following administration of L-DOPA (Item No. 13248) in rats. Benserazide (10 and 50 mg/kg) also inhibits striatal AADC and increases striatal dopamine levels following administration of L-DOPA in a 6-OHDA (Item No. 25330) mouse model of Parkinson's disease.{32006}

Size	2.5 mg
Shipping	dry ice
Molecular Formula	C₁₀H₁₂D₃N₃O₅ • HCl
SMILES	OC1=C(O)C=CC(CNNC(C(N)([2H])C([2H])([2H])O)=O)=C1O.Cl
Molecular Weight	296,7
Formulation	A solid
Purity	≥99% deuterated forms (d1-d3)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.