L-Cysteinesulfinic Acid (hydrate

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L-Cysteinesulfinic Acid (hydrate)

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Cat No: 29597

Biochemicals - Receptor Pharmacology

L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs).{49465,49466} It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC50s = 120, 30, and 110...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-sulfino-L-alanine, monohydrate

Correlated keywords:

105937-15-3 1400814-44-9 1115-65-7 Cysteine sulfinic mGluR-1 mGluR-5 mGluR-8 mGluR-2 mGluR-6 mGluR-1? micro-injected

Product Overview:
L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs).{49465,49466} It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC50s = 120, 30, and 110 μM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC50s = 100, 100, and 2,000 μM, respectively).{49466} It selectively binds to mGluR1α (Ki = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (Kis = >10,000 nM for all). L-Cysteinesulfinic acid (1 mM) decreases mean arterial blood pressure and heart rate in rats when microinjected into the nucleus tractus solitarius (NTS).{49465} L-Cysteinesulfinic acid can be formed via oxidation of L-cysteine by reactive oxygen species (ROS), and conversion of cysteine to L-cysteinesulfinic acid in cysteine-containing peptide probes has been used to measure oxidative stress.{49467}

Size	25 mg
Shipping	dry ice
CAS Number	207121-48-0,
Molecular Formula	C₃H₇NO₄S • H₂O
SMILES	OC([C@@H](N)CS(O)=O)=O.O
Molecular Weight	171,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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