Penbutolol (hemisulfate)

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Cat No: 29524

Biochemicals - Receptor Pharmacology

Penbutolol is an antagonist of β-adrenergic receptors (β-ARs; IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM).{53262} It inhibits adenylate cyclase activity induced by the β-AR agonist isoprenaline (isoproterenol; Item ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2S)-1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol, hemisulfate

Correlated keywords:

38363-40-5 42208-19-5 52767-15-4 Levo Levopenbutolol (S)-penbutolol (-)-Terbuclomine Levatol Paginol HOE-39893d HOE39893d 5HT1A ?AR 5HT

Product Overview:
Penbutolol is an antagonist of β-adrenergic receptors (β-ARs; IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM).{53262} It inhibits adenylate cyclase activity induced by the β-AR agonist isoprenaline (isoproterenol; Item No. 15592) in guinea pig myocardial membranes with a Ki value of 2.4 nM.{53263} Penbutolol reduces basal renin activity and blood pressure in spontaneously hypertonic rats.{53264} It decreases isolation-induced aggressive behavior in mice (ED50 = 56 µmol/kg) and reverses reductions in aggression induced by 8-hydroxy-DPAT (Item No. 22608) and TFMPP with ED50 values of 8.1 and 2.1 µmol/kg, respectively.{53262} Formulations containing penbutolol were previously used in the treatment of arterial hypertension.

Size	5 mg
Shipping	dry ice
CAS Number	38363-32-5
Molecular Formula	C₁₈H₂₉NO₂ • 1/2H₂SO₄
SMILES	O[C@@H](CNC(C)(C)C)COC1=C(C2CCCC2)C=CC=C1.O=S(O)(O)=O.O[C@@H](CNC(C)(C)C)COC3=C(C4CCCC4)C=CC=C3
Molecular Weight	340,5
Formulation	A solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.