7-hydroxy DPAT (hydrobromide)

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Cat No: 29516

Biochemicals - Receptor Pharmacology

7-hydroxy DPAT is a dopamine D3 receptor agonist.{52357} It selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.78, 61, 650, and 5,300 nM, respectively, in radioligand binding assays). 7-hydroxy DPAT increases calcium mobil...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7-(dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol, monohydrobromide

Correlated keywords:

159795-63-8 74938-11-7 D 1 2 3 4 HEK 293 HBR 6OHDA

Product Overview:
7-hydroxy DPAT is a dopamine D3 receptor agonist.{52357} It selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.78, 61, 650, and 5,300 nM, respectively, in radioligand binding assays). 7-hydroxy DPAT increases calcium mobilization in HEK293 cells expressing the D3 receptor with an EC50 value of 13.5 nM in a FLIPR assay.{52358} It decreases the release of striatal dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC; Item No. 24912) in rats when administered intraperitoneally at a dose of 0.25 mg/kg.{52359} 7-hydroxy DPAT (2 µg/µl for eight weeks, i.c.v.) reduces the loss of ipsilateral substantia nigra pars compacta (SNC) dopaminergic neurons in a rat model of Parkinson's disease induced by 6-OHDA (Item No. 25330).{52360} It also decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model.

Size	5 mg
Shipping	dry ice
CAS Number	76135-30-3
Molecular Formula	C₁₆H₂₅NO • HBr
SMILES	CCCN(CCC)C1CCC2=CC=C(O)C=C2C1.Br
Molecular Weight	328,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2921.49
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.