Mitoxantrone-d8

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Mitoxantrone-d₈

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Cat No: 29414

Mitoxantrone-d8 is intended for use as an internal standard for the quantification of mitoxantrone (Item No. 14842) by GC- or LC-MS. Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiti...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl-1,1,2,2-d4)amino]ethyl]amino]-9,10-anthracenedione

Correlated keywords:

deuterated deuterium GCMS LCMS NCI 301739 NCI301739 Novantrone NSC 301739 NSC301739 HIV1 K-562 HEK-293T ACE-2 OVID19 SARSCoV2 SARS-CoV2 SARSCoV

Product Overview:
Mitoxantrone-d8 is intended for use as an internal standard for the quantification of mitoxantrone (Item No. 14842) by GC- or LC-MS. Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation.{23708,23705} It also inhibits HIV-1 integrase (IC50 = 3.8 μM).{23704} Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1.{23706} Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.{23702,23707,23703}

Size	1 mg
Shipping	dry ice
CAS Number	1189974-82-0
Molecular Formula	C₂₂H₂₀D₈N₄O₆
SMILES	O=C1C2=C(C(O)=CC=C2O)C(C3=C1C(NCCNC([2H])([2H])C([2H])([2H])O)=CC=C3NCCNC([2H])([2H])C([2H])([2H])O)=O
Molecular Weight	452,5
Formulation	A solid
Purity	≥99% deuterated forms (d1-d8)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.