Tau Polyclonal Antibody

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Cat No: 29296

Tau is a member of the microtubule-associated protein (MAP) family that facilitates microtubule formation in axons.{55125,55126} It is primarily expressed in neurons and localized to axons, but trace amounts have been observed in glial cells and sever...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

anti-body MTBT 2 FTDP17 AI413597 AW045860 DDPAC FLJ31424 FTDP 17 MAPT g protein MAPTL MGC134287 134287 MGC138549 138549 MGC156663 156663 MGC MSTD MTBT1 MTBT2 MTBT 1 2 PHF PPND PPP1R103 pTau RNPTAU

Product Overview:
Tau is a member of the microtubule-associated protein (MAP) family that facilitates microtubule formation in axons.{55125,55126} It is primarily expressed in neurons and localized to axons, but trace amounts have been observed in glial cells and several peripheral tissues including kidney, lung, and testis. Tau is composed of an N-terminal projection domain that interacts with neurofilaments, cytoplasmic organelles, and neuronal cell membranes and a C-terminal microtubule binding domain that facilitates microtubule polymerization and stabilization. It is encoded by MAPT in humans, a 16-exon gene that produces 6 isoforms via alternative mRNA splicing. Mutations in MAPT lead to changes in expression of tau isoforms and the formation of insoluble protein aggregates that cause familial frontotemporal dementia (FTD) and parkinsonism linked to chromosome 17 (FTDP-17).{55127} Tau is subject to post-translational modifications, including phosphorylation, and hyperphosphorylation of tau is associated with the formation of neurofibrillary tangles and neuronal cell death in postmortem brains from patients with Alzheimer's disease. Cayman's Tau Polyclonal Antibody can be used for immunohistochemistry (IHC), immunocytochemistry (ICC), and Western blot (WB) applications. The antibody recognizes three isoforms of tau at approximately 48, 65, and 75 kDa from human, bovine, mouse, porcine, and rat samples.

Size	100 µl
Shipping	dry ice
Host	Chicken
Antigen	Full-length recombinant human tau
Application(s)	IHC, ICC, WB
Formulation	100 µl of Affinity-purified chicken polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.