SNAP-25 (Phospho-Ser187) Polyclo

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SNAP-25 (Phospho-Ser¹⁸⁷) Polyclonal Antibody

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Cat No: 29294

Synaptosomal-associated protein 25 (SNAP-25) is a member of the SNARE complex, which also includes syntaxin and VAMP, that is responsible for fusing synaptic vesicles with the presynaptic plasma membrane to facilitate neurotransmitter release.{55160} ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Phosphoser-187 SNAP25 bA416N4.2 Bdr CMS18 CMS-18 dJ1068F16.2 FLJ23079 MGC105414 MGC139754 RIC4 RIC-4 SEC-9 SEC9 SNAP25B SNAP25A SNP25 VGCC Ser-187 S-187A S187-A

Product Overview:
Synaptosomal-associated protein 25 (SNAP-25) is a member of the SNARE complex, which also includes syntaxin and VAMP, that is responsible for fusing synaptic vesicles with the presynaptic plasma membrane to facilitate neurotransmitter release.{55160} Two SNAP-25 isoforms, SNAP-25a and SNAP-25b, are generated through alternative splicing, with SNAP-25b expressed only during the postnatal period and as the predominant isoform in the brain.{55161} SNAP-25 contains two α helices, as well as one large and several smaller intrinsically disordered domains.{55160} SNAP-25 is located primarily on the intracellular side of the presynaptic plasma membrane in neurons and interacts with a variety of proteins to orchestrate vesicle fusion in a calcium-triggered manner and to mediate spine development.{55160} It is also found in the pancreas, enteroendocrine cells, and the chromaffin cells of the adrenal medulla where it is involved in hormone secretion.{55161} SNAP-25 can be phosphorylated at serine 187 (Ser187) in a neuronal activity-dependent manner by PKC, a modification that increases the rate of synaptic vesicle recruitment and is essential for SNAP-25b inhibition of voltage-gated calcium channels (VGCCs) and incorporation of NMDA receptors into the postsynaptic membrane.{55154,55155,55156} Phosphorylation at Ser187 also facilitates neurotransmitter release and inhibits presynaptic short-term plasticity via regulation of synaptic vesicle dynamics.{55157} A point mutation at Ser187 (S187A) induces anxiety-like behavior in mice homozygous for the mutation and induces working memory deficits and an immature phenotype in hippocampal dental granule cells of adult mice heterozygous for the mutation.{55158,55159} Cayman’s SNAP-25 (Phospho-Ser187) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes SNAP-25 (phospho-Ser187) at approximately 25 kDa from mouse and rat samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser187 of rat SNAP-25
Application(s)	WB
Formulation	100 µl of affinity-purified rabbit polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.