KCC2 (Phospho-Ser940) Polyclonal

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KCC2 (Phospho-Ser⁹⁴⁰) Polyclonal Antibody

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Cat No: 29291

The neuronal-specific potassium chloride cotransporter 2 (KCC2) is a member of the SLC12 family of transporters and is encoded by SLC12A5 in humans.{55121} KCC2 is expressed in mature neurons throughout the CNS and localizes to the soma and dendrite p...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

KCC Ser anti body AA SLC 12 SLC12A 5 SLC 12A5 HEK 293 S940 A

Product Overview:
The neuronal-specific potassium chloride cotransporter 2 (KCC2) is a member of the SLC12 family of transporters and is encoded by SLC12A5 in humans.{55121} KCC2 is expressed in mature neurons throughout the CNS and localizes to the soma and dendrite plasma membrane where it mediates chloride ion efflux, maintaining the transmembrane chloride potential.{55122} It consists of 12 transmembrane helices, which contain an extracellular loop subject to N-glycosylation, as well as intracellular N- and C-terminal domains with sites that are subject to phosphorylation. Phosphorylation of KCC2 at serine 940 (Ser940) is mediated by PKC and regulates KCC2 stability and expression.{55121,55123} KCC2 (phospho-Ser940) levels are increased by the PKC activator phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in primary rat embryonic hippocampal neurons.{55123} HEK293 cells expressing a point mutation of Ser940 (S940A) in KCC2, which abolishes its phosphorylation, have a reduced rate of ion transport and decreased KCC2 endocytosis. Mice expressing S940A have reduced latency to first seizure and increased mortality in a mouse model of status epilepticus induced by kainate.{55124} Cayman's KCC2 (Phospho-Ser940) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes KCC2 (Phospho-Ser940) at approximately 135 kDa from mouse and rat samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser940 of rat KCC2
Application(s)	WB
Formulation	100 µl of affinity-purified rabbit polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.