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- Phospholipase C ?2 Polyclonal Antibody
Phospholipase C ?2 Polyclonal Antibody
Cat No: 29290
Phospholipase C β2 (PLCβ2) is an enzyme that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the secondary messengers inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).{59155,59156} It is approximately 135 kDa and is comp...
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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
- PLC-?2 PLC?-2 ? IP-3 G?- 11q T-1R T1-R 2R T2 16 Plcbb
Product Overview:
Phospholipase C β2 (PLCβ2) is an enzyme that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the secondary messengers inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).{59155,59156} It is approximately 135 kDa and is composed of a pleckstrin homology domain, four EF-hand motifs, a catalytic domain, and a C2 domain that are common to all PLCs, as well as a 400-amino acid C-terminal region that is required for PLCβ2 activation by the G-protein subunits Gαq or Gα11.{59157} PLCβ2 is also activated by Gβγ subunits. Upon activation by a G-protein subunit, PLCβ2 initiates intracellular signal transduction of extracellular signals using calcium as a cofactor. PLCβ2 colocalizes with T1R and T2R taste receptors and Plcb2-/- mice exhibit selective and complete loss of sweet, amino acid, and bitter tastes.{59158} Plcb2-/- mice also exhibit increased coxsackievirus A16-induced pro-inflammatory cytokine production and decreased survival compared with wild-type mice.{59159} Cayman's Phospholipase C β2 Polyclonal Antibody can be used for immunohistochemistry (IHC) and immunofluorescence (IF) applications.
Phospholipase C β2 (PLCβ2) is an enzyme that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the secondary messengers inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).{59155,59156} It is approximately 135 kDa and is composed of a pleckstrin homology domain, four EF-hand motifs, a catalytic domain, and a C2 domain that are common to all PLCs, as well as a 400-amino acid C-terminal region that is required for PLCβ2 activation by the G-protein subunits Gαq or Gα11.{59157} PLCβ2 is also activated by Gβγ subunits. Upon activation by a G-protein subunit, PLCβ2 initiates intracellular signal transduction of extracellular signals using calcium as a cofactor. PLCβ2 colocalizes with T1R and T2R taste receptors and Plcb2-/- mice exhibit selective and complete loss of sweet, amino acid, and bitter tastes.{59158} Plcb2-/- mice also exhibit increased coxsackievirus A16-induced pro-inflammatory cytokine production and decreased survival compared with wild-type mice.{59159} Cayman's Phospholipase C β2 Polyclonal Antibody can be used for immunohistochemistry (IHC) and immunofluorescence (IF) applications.
| Size | 100 µl |
| Shipping | dry ice |
| Host | Rabbit |
| Antigen | Peptide from the C-terminal region of human PLC?2 |
| Application(s) | IHC, IF |
| Formulation | 100 µl of affinity-purified polyclonal antibody from pooled serum |
| Custom Code | 3822.19 |
| UNSPSC code | 12352203 |
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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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