Olig2 (Phospho-Ser10,13,14) Poly

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Olig2 (Phospho-Ser^10,13,14) Polyclonal Antibody

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Cat No: 29289

Oligodendrocyte lineage transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor that is essential to the formation of oligodendrocytes and motor neurons in the spinal cord and somatic motor neurons in the hindbrain.{46965} It r...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Ser Oligo BHLHB bHLHB1 bHLHe19 PRKCBP2 OTTHUMP00000067570 OTTHUMP00000067569 RACK17 17 Olig Anti body WT AA

Product Overview:
Oligodendrocyte lineage transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor that is essential to the formation of oligodendrocytes and motor neurons in the spinal cord and somatic motor neurons in the hindbrain.{46965} It represses differentiation and sustains the replication-competent state of uncommitted progenitor cells to expand the progenitor cell pool during early development and promotes the cell fate decision to form oligodendrocyte progenitors and motor neurons in the spinal cord during late development. It also suppresses the formation of astrocytes in the spinal cord. Olig2 contains a triple serine motif at positions 10, 13, and 14 near its amino terminus that is subject to phosphorylation.{46966} Phosphorylation of Olig2 at this motif (phospho-Ser10,13,14) is developmentally regulated and decreases as Olig2+ progenitor cells mature into terminally differentiated oligodendrocytes. EB5 neurospheres expressing a triple phosphomimetic mutant of Olig2 induce more rapid tumor formation and decreased survival in mice compared with neurospheres expressing wild-type Olig2. Cayman's Olig2 (Phospho-Ser10,13,14) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes Olig2 (phospho-Ser10,13,14) at approximately 32 kDa from human, mouse, and rat samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser10,13,14 of human Olig2
Application(s)	WB
Formulation	100 µl of Affinity-purified rabbit polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.