Olig1 Polyclonal Antibody

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Cat No: 29287

Oligodendrocyte lineage transcription factor 1 (Olig1) is a basic helix-loop-helix transcription factor that promotes the formation and maturation of oligodendrocytes.{55117} It is expressed in the spinal cord and neuroepithelium of the ventral forebr...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Oligo-dendrocyte-Specific BHLH Olig Oligo-1 Sox-10 BHLH-B6 BHLHB 6 bHLHe21

Product Overview:
Oligodendrocyte lineage transcription factor 1 (Olig1) is a basic helix-loop-helix transcription factor that promotes the formation and maturation of oligodendrocytes.{55117} It is expressed in the spinal cord and neuroepithelium of the ventral forebrain, colocalizing with the oligodendrocyte precursor markers Sox10 and Pdgfra. Olig1 is localized to the nucleus at the embryonic stage and is translocated to the cytoplasm after birth.{55118} However, Olig1 is translocated back to the nucleus of oligodendrocyte precursors following a demyelinating injury. Olig1-/- mice exhibit delayed, but not impaired, spinal cord oligodendrocyte differentiation and maturation, indicating that Olig1 is non-essential to oligodendrocyte differentiation.{55119} Olig1 knockdown delays mean disease onset and reduces disease severity in a mouse model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.{55120} Cayman's Olig1 Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes Olig1 at approximately 27 kDa from human, mouse, and rat samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Recombinant mouse Olig1
Application(s)	ICC, IHC, IP, WB
Formulation	100 µl of protein A-purified rabbit polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.