Mitochondrial Fission Factor Pol

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Mitochondrial Fission Factor Polyclonal Antibody

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Cat No: 29284

Mitochondrial fission factor (MFF) is a tail-anchored membrane protein with roles in mitochondrial and peroxisomal fission.{55234,59142} It is localized to the outer membrane of mitochondria, as well as the membrane-restricted regions of elongated per...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

DRP-1 PC-3

Product Overview:
Mitochondrial fission factor (MFF) is a tail-anchored membrane protein with roles in mitochondrial and peroxisomal fission.{55234,59142} It is localized to the outer membrane of mitochondria, as well as the membrane-restricted regions of elongated peroxisomes. It is composed of a cytoplasmic N-terminus that functions as a receptor for the GTPases dynamin-related protein 1 (DRP1) and dynamin-like protein 1 (DLP1), a central coiled-coil domain, and a C-terminal transmembrane domain.{59144} siRNA knockdown of MFF inhibits DRP1 recruitment and mitochondrial fission induced by loss of mitochondrial membrane potential and delays cytochrome c release from mitochondria and apoptotic progression in vitro.{55234,59144} MicroRNA knockdown of MFF inhibits norepinephrine-induced hypertrophy and mitochondrial fission in isolated neonatal rat ventricular cells.{59144} MFF is overexpressed in various cancer cells and knockdown of MFF reduces tumor volume in a PC3 mouse xenograft model.{59143} Cayman's Mitochondrial Fission Factor Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes MFF at approximately 38 kDa from human, bovine, and mouse samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Recombinant human MFF
Application(s)	IHC, WB
Formulation	100 µl of polyclonal antibody neat serum
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.