MAP2 (bovine) Monoclonal Antibod

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MAP2 (bovine) Monoclonal Antibody (Clone 4H5)

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Cat No: 29280

Microtubule-associated protein 2 (MAP2) belongs to the microtubule-associated protein (MAP) family of cytoskeletal filament proteins, which includes MAP1-5 and tau.{55112} MAP2 is composed of an N-terminal projection domain that interacts with PKA and...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

MAP-2 1 2a 2c 2b MARK-2 4-H-5 H5 4H

Product Overview:
Microtubule-associated protein 2 (MAP2) belongs to the microtubule-associated protein (MAP) family of cytoskeletal filament proteins, which includes MAP1-5 and tau.{55112} MAP2 is composed of an N-terminal projection domain that interacts with PKA and a C-terminal domain that contains microtubule binding repeats containing a KXGS motif that is subject to phosphorylation.{55113} Five isoforms of MAP2 are generated through alternative splicing and are found in the cell body and dendrites of neurons, with some isoforms also found in astrocytes and oligodendrocytes of the CNS and in the testis.{55113,55112} MAP2 is expressed in mature neurons, with the MAP2a and MAP2c isoforms expressed in a developmental stage-dependent manner while the MAP2b isoform is expressed throughout development and adulthood.{55114,55112} MAP2 binds to and stabilizes microtubules and increases their rigidity, as well as interacts with F-actin during neurite initiation and with proteins involved in signal transduction.{55113} Phosphorylation of the KXGS motif by MAP/microtubule affinity-regulating kinase 1 (MARK1), MARK2, or PKA decreases the affinity of MAP2 for microtubules, and the detachment of MAP2 leads to microtubule destabilization and disassembly. Decreased levels of MAP2 protein have been found in postmortem brain tissue from patients with a Lewy body variant of Alzheimer’s disease.{55115} MAP2 has been found in cytoplasmic neuronal Lewy bodies colocalized with α-synuclein and ubiquitin in postmortem substantia nigra from patients with Parkinson’s disease.{55116} Cayman’s MAP2 (bovine) Monoclonal Antibody (Clone 4H5) can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes MAP2 at approximately 280 kDa from human, bovine, mouse, and rat samples.

Size	100 µl
Shipping	dry ice
Host	Mouse
Antigen	Purified bovine MAP2
Application(s)	ICC, IHC, WB
Formulation	100 µl of protein G-purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.