GluR2/3 Polyclonal Antibody

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Cat No: 29279

AMPA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission.{46955,46957} They are tetrameric protein complexes expressed throughout the central nervous system in both neurons and glia that are assembled from combin...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

GRIA3 GRIA2 GluR B K2 GluR K3 GLURB GLURC GLUTAMATE RECEPTOR 2 3 ionotropic AMPA GRM3 MGR3 MGR GRM

Product Overview:
AMPA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission.{46955,46957} They are tetrameric protein complexes expressed throughout the central nervous system in both neurons and glia that are assembled from combinations of GluR1, GluR2, GluR3, and GluR4, also known as GluR-A-D, subunits, each of which has extracellular N-terminal and ligand binding domains, a channel domain consisting of three membrane-spanning helices and a channel pore loop, and an intracellular C-terminus.{46955,46956,46958,46959} GluR1 and GluR2 are predominantly expressed in the forebrain, with low levels of GluR3 and GluR4, and pyramidal neurons express AMPA receptors primarily comprised of heterotetramers of GluR1 and GluR2 subunits. Hippocampal pyramidal neurons also express AMPA receptors composed of GluR2 and GluR3 (GluR2/3) that cycle into and out of synapses constitutively.{46952} Protein levels of GluR2/3 are decreased in postmortem enterorhinal cortex, frontal cortex, and Purkinje cell samples from patients with sporadic Creutzfeldt-Jakob disease.{46953} GluR2/3 protein levels are increased on the dendrites of dentate granule cells in postmortem epileptogenic hippocampus samples from patients with temporal lobe epilepsy.{46954} Cayman's GluR2/3 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes GluR2/3 at approximately 100 kDa from rat samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3
Application(s)	WB
Formulation	100 µl of affinity-purified rabbit polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.