GluR2 Polyclonal Antibody

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Cat No: 29278

AMPA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission.{46955,46957} They are tetrameric protein complexes expressed throughout the CNS in both neurons and glia that are assembled from combinations of GluR1, Gl...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

central nervous system GluR 1 2 3 4 GluRAD GlurA AD GRIA SOD 1G39A ALS post mortem AMPA2 GluRB K2 HBGR2

Product Overview:
AMPA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission.{46955,46957} They are tetrameric protein complexes expressed throughout the CNS in both neurons and glia that are assembled from combinations of GluR1, GluR2, GluR3, and GluR4, also known as GluR-A-D, subunits, each of which has extracellular N-terminal and ligand-binding domains, a channel domain consisting of three membrane-spanning helices and a channel pore loop, and an intracellular C-terminus.{46955,46956,46958,46959} GluR1 and GluR2 are predominantly expressed in the forebrain with low levels of GluR3 and GluR4, and pyramidal neurons express AMPA receptors primarily comprised of heterotetramers of GluR1 and GluR2 subunits. GluR2 is encoded by GRIA2 and regulates AMPA receptor calcium permeability, assembly, trafficking, and single channel conductance.{46955,56145} It undergoes RNA editing at position 586, the Q/R site, to introduce an arginine residue that renders GluR2 subunit-containing AMPA receptors impermeable to calcium.{46955,56145,56146} Motor neurons isolated from Gria2-deficient mouse embryos exhibit increased calcium influx and increased susceptibility to AMPA receptor-mediated excitotoxicity.{56146} Heterozygous knockdown of Gria2 accelerates motor neuron degradation and decreases lifespan in the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis. GRIA2 expression is reduced in postmortem hippocampus from patients with chronic schizophrenia.{56147} Cayman's GluR2 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody detects GluR2 at approximately 100 kDa from rat samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to amino acid residues from rat GluR2, conjugated to keyhole limpet hemocyanin (KLH)
Application(s)	WB
Formulation	100 ?l of affinity-purified polyclonal antibody from pooled serum
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.