GluR1 Monoclonal Antibody

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Cat No: 29277

AMPA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission.{46957,46955} They are tetrameric protein complexes expressed throughout the central nervous system in both neurons and glia that are assembled from combin...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

GluA GRIA GluR-1 2 3 4 A B C D K1 AMPA1 GluRA GluRK1 glutamate receptor ionotropic RH-95 IgG-2a

Product Overview:
AMPA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission.{46957,46955} They are tetrameric protein complexes expressed throughout the central nervous system in both neurons and glia that are assembled from combinations of GluR1, GluR2, GluR3, and GluR4, also known as GluR-A-D, subunits, each of which has extracellular N-terminal and ligand binding domains, a channel domain consisting of three membrane-spanning helices and a channel pore loop, and an intracellular C-terminus.{46955,46956,46958,46959} The GluR1 subunit, which is encoded by GRIA1 in humans, is primarily expressed in the forebrain and hippocampus. Mice lacking the GluR1 subunit exhibit normal spatial reference memory but have deficits in spatial working memory.{46957} They also exhibit increased and decreased duration of nocifensive behaviors in phases I and II, respectively, of the formalin test, as well as increased duration of nocifensive behaviors in response to intraplantar injection of capsaicin (Item No. 92350), compared with wild-type mice.{55099} SNPs in GRIA1 have been found in patients with bipolar disorder with psychotic features.{46958} Elevated levels of GRIA1 mRNA have been found in postmortem dorsolateral prefrontal cortex from patients with schizophrenia.{55100} Cayman's GluR1 Monoclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes GluR1 at approximately 105 kDa from mouse and rat samples.

Size	100 µl
Shipping	dry ice
Host	Mouse
Antigen	Peptide corresponding to amino acid residues from the N-terminal region of rat GluR1
Clone	RH95
Isotype	IgG2a
Application(s)	WB
Formulation	100 µl of protein G-purified mouse monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.