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- GABAA Receptor ?2 Subunit Polyclonal Antibody
GABAA Receptor ?2 Subunit Polyclonal Antibody
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Cat No: 29268
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1...
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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
- GABA A ? 2 3 5 post synaptic ?6 ?4 ?3 ?3 ?2 ?2 SL 651498 GABRA
Product Overview:
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The α subunit of GABAA receptors interfaces with a β subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. Activation of GABAA receptors with the α2/α3-selective GABAA receptor agonist SL651498, but not the α5/α3 selective GABAA receptor positive allosteric modulator NS 11394 (Item No. 23872), suppresses cortical spreading depression, the underlying cause of migraine, in isolated chick retina.{55214} Point mutation of the histidine residue at position 101 (H101R) of the GABAA α2 subunit inhibits muscle relaxation and the anxiolytic-like effects of the benzodiazepine diazepam in mice.{46949} Expression of GABRA2, which encodes the α2 subunit isoform, is upregulated in ipsilateral, but not contralateral, perilesional tissue in a rat model of cortical ischemia-reperfusion injury.{55094} Cayman's GABAA Receptor α2 Subunit Polyclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications. The antibody recognizes the GABAA receptor α2 subunit at approximately 51 kDa from murine samples.
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The α subunit of GABAA receptors interfaces with a β subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. Activation of GABAA receptors with the α2/α3-selective GABAA receptor agonist SL651498, but not the α5/α3 selective GABAA receptor positive allosteric modulator NS 11394 (Item No. 23872), suppresses cortical spreading depression, the underlying cause of migraine, in isolated chick retina.{55214} Point mutation of the histidine residue at position 101 (H101R) of the GABAA α2 subunit inhibits muscle relaxation and the anxiolytic-like effects of the benzodiazepine diazepam in mice.{46949} Expression of GABRA2, which encodes the α2 subunit isoform, is upregulated in ipsilateral, but not contralateral, perilesional tissue in a rat model of cortical ischemia-reperfusion injury.{55094} Cayman's GABAA Receptor α2 Subunit Polyclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications. The antibody recognizes the GABAA receptor α2 subunit at approximately 51 kDa from murine samples.
| Size | 100 µl |
| Shipping | dry ice |
| Host | Rabbit |
| Antigen | Fusion protein from the cytoplasmic loop of the ?2 subunit of the rat GABAA receptor |
| Application(s) | ICC, WB |
| Formulation | 100 µl of affinity-purified polyclonal antibody from pooled serum |
| Custom Code | 3822.19 |
| UNSPSC code | 12352203 |
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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
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