Connexin43 Polyclonal Antibody

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Cat No: 29257

Connexin43 (Cx43) is a membrane protein and member of the connexin family that is encoded by GJA1 in humans.{55146,55147} It is widely expressed across various tissues, including the heart, brain, and retina, and exhibits plasma membrane localization....

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

?-1 AVSD-3 AVS-D3 Cx-43 Connexin-43

Product Overview:
Connexin43 (Cx43) is a membrane protein and member of the connexin family that is encoded by GJA1 in humans.{55146,55147} It is widely expressed across various tissues, including the heart, brain, and retina, and exhibits plasma membrane localization. Cx43 is a monomeric component of connexons, homo- or heterohexamers that form hydrophilic pores and facilitate the exchange of ions and secondary messengers between the cytoplasm of connected cells at gap junctions. It is essential to cardiomyocyte function and cardiac development, osteoblast and osteocyte survival, and spermatogenesis.{55146} Cx43 is also expressed in various tumor cells, including in the liver, prostate, and breast, and exhibits tumor-specific pro- or anti-metastatic effects.{55146,55148} Inhibition of Gja1 with antisense oligonucleotides promotes wound healing in murine skin, skeletal muscle, cardiac tissue, and vascular endothelium, however, global heterozygous knockdown of Gja1 increases infarct size in a mouse model of ischemia and reperfusion injury.{55146,55147} Levels of Cx43 are decreased in postmortem retinal samples from patients with diabetes compared with control individuals.{55149} Cayman's Connexin43 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes connexin43 at approximately 43 kDa from rat samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43
Application(s)	WB
Formulation	100 µl of protein affinity-purified polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.