Adenylate Cyclase Type 3 Polyclo

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Adenylate Cyclase Type 3 Polyclonal Antibody

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Cat No: 29250

Adenylate cyclase type 3 (AC3) is a membrane-bound protein that catalyzes the formation of the second messenger cAMP from ATP (Item No. 14498) in response to G protein-coupled receptor (GPCR) signaling.{55136,55137} It consists of 1,144 amino acids an...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

AC-3 ADCY-3 III

Product Overview:
Adenylate cyclase type 3 (AC3) is a membrane-bound protein that catalyzes the formation of the second messenger cAMP from ATP (Item No. 14498) in response to G protein-coupled receptor (GPCR) signaling.{55136,55137} It consists of 1,144 amino acids and is comprised of a cytoplasmic N-terminus followed by two repeating modules, each consisting of a transmembrane domain and a cytoplasmic domain, with the transmembrane domains composed of six membrane-spanning helices apiece.{55135,55136} ADCY3, the gene encoding AC3, is expressed in a variety of tissues, with high levels in the placenta, testes, ovaries, and colon in humans.{55136,55135} AC3 also localizes to primary cilia in the brain and has been used as a marker of primary cilia in mouse brain.{55138,55139} Mutations in ADCY3 are associated with an increased risk of obesity and type 2 diabetes.{55137,55135,55138} Cayman's Adenylate Cyclase Type 3 Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes AC3 at approximately 160 kDa from human, mouse, and rat samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Synthetic peptide corresponding to the C-terminal region of rat adenylate cyclase type 3 conjugated to KLH
Application(s)	WB, IHC, ICC
Formulation	100 µl of affinity-purified polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.