Zotarolimus

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Zotarolimus

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Cat No: 29246

Biochemicals - More Biochemicals

Zotarolimus is a macrocyclic lactone immunosuppressant and a derivative of rapamycin (Item No. 13346).{48775,48776} It binds to FKBP prolyl isomerase 1A (FKBP12; IC50 = 2.57 nM) and inhibits proliferation of human peripheral blood mononuclear cells (P...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(42S)-42-deoxy-42-(1H-tetrazol-1-yl)-rapamycin

Correlated keywords:

916135-04-1 FKBP 12 A179578 Endeavor Resolute

Product Overview:
Zotarolimus is a macrocyclic lactone immunosuppressant and a derivative of rapamycin (Item No. 13346).{48775,48776} It binds to FKBP prolyl isomerase 1A (FKBP12; IC50 = 2.57 nM) and inhibits proliferation of human peripheral blood mononuclear cells (PBMCs), rat splenocytes, and human coronary artery smooth muscle cells (IC50s = 7, 1,337, and 0.8 nM, respectively).{48776} Zotarolimus has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC50s = 1.2 and 1,465 nM, respectively). It also reduces symptom severity in a rat model of experimental autoimmune encephalomyelitis (EAE; ED50 = 1.17 mg/kg per day) and delays cardiac allograft rejection in rats (ED50 = 3.71 mg/kg per day). Zotarolimus inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 µg/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis.{48775} Formulations containing zotarolimus have been used in drug-eluting stents in the prevention of restenosis following stent placement.

Size	1 mg
Shipping	dry ice
CAS Number	221877-54-9
Molecular Formula	C₅₂H₇₉N₅O₁₂
SMILES	O=C([C@H](OC)[C@@H](/C(C)=C/[C@@H](C)C(C[C@]([H])(OC([C@]1([H])CCCCN12)=O)[C@@H](C[C@@H]3CC[C@@](N4C=NN=N4)([H])[C@H](OC)C3)C)=O)O)[C@@H](C[C@@H](/C=C/C=C/C=C(C)/[C@H](C[C@@]5([H])O[C@](C(C2=O)=O)(O)[C@H](C)CC5)OC)C)C
Molecular Weight	966,2
Formulation	A solid
Purity	≥95% (mixture of isomers)
Custom Code	2934.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.