Leucettine L<sub>41</sub>

Leucettine L41

CAT N°: 29225
Price:

From 92.00 78.20

Leucettine L41 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 µM, respectively).{53108} It also inhibits GSK3?/? and Pim1 with IC50 values of 0.41 and 4.1 µM, respectively. It inhibits phosphorylation of the serine/arginine (SR) protein 9G8 by DYRK2, DYRK3, CLK1, CLK2, and CLK4 and inhibits TNF-?-induced SRp75 and SRp55 phosphorylation in human microvascular endothelial cells when used at concentrations ranging from 0.1 to 10 µM. Leucettine L41 modulates alternative pre-RNA splicing of a synthetic CLK1 minigene in a reporter model. It prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by amyloid-? 25-35 (Item No. 24155) in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity.{53109} Leucettine L41 (0.4, 1.2, and 4 µg, i.c.v.) also prevents memory deficits induced by amyloid-? 25-35 in the same model.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (5Z)-5-(1,3-benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-4H-imidazol-4-one
  • Correlated keywords
    • L-41 DYRK-1A 2 CLK-1 2 3 4 GSK3-? GSK3? Pim-1 TNF? SRp-75 55 SR-p75 p55
  • Product Overview:
    Leucettine L41 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 µM, respectively).{53108} It also inhibits GSK3?/? and Pim1 with IC50 values of 0.41 and 4.1 µM, respectively. It inhibits phosphorylation of the serine/arginine (SR) protein 9G8 by DYRK2, DYRK3, CLK1, CLK2, and CLK4 and inhibits TNF-?-induced SRp75 and SRp55 phosphorylation in human microvascular endothelial cells when used at concentrations ranging from 0.1 to 10 µM. Leucettine L41 modulates alternative pre-RNA splicing of a synthetic CLK1 minigene in a reporter model. It prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by amyloid-? 25-35 (Item No. 24155) in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity.{53109} Leucettine L41 (0.4, 1.2, and 4 µg, i.c.v.) also prevents memory deficits induced by amyloid-? 25-35 in the same model.

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