PEPA - C16H16F2N2O4S2 - Bertin Bioreagent

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PEPA

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Cat No: 29190

Biochemicals - Ion Channel Modulation

PEPA is a positive allosteric modulator (PAM) of AMPA receptors.{52115} It selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits glutamate receptor 3 (GluR3) and GluR4 over the...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-acetamide

Correlated keywords:

Xenopus GluR-3

Product Overview:
PEPA is a positive allosteric modulator (PAM) of AMPA receptors.{52115} It selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits glutamate receptor 3 (GluR3) and GluR4 over the flip isoforms of these subunits at 200 µM. PEPA (10 mg/kg) decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, in a rat model of memory impairment induced by middle cerebral artery occlusion (MCAO).{52116} It decreases freezing time in a contextual fear freezing paradigm in mice when administered at a dose of 30 mg/kg.{52117}

Size	5 mg
Shipping	dry ice
CAS Number	141286-78-4
Molecular Formula	C₁₆H₁₆F₂N₂O₄S₂
SMILES	FC1=C(OCC(N)=O)C(F)=CC(SCCNS(C2=CC=CC=C2)(=O)=O)=C1
Molecular Weight	402,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2935.90
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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