CPI-1189

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CPI-1189

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Cat No: 29187

Biochemicals - More Biochemicals

CPI-1189 is a benzamide with neuroprotective and anti-inflammatory activities.{45675,45676,45677,45678,45679} It inhibits phosphorylation of p38 MAPK in IL-1β-stimulated primary rat astrocytes by 70 to 80% when used at concentrations ranging from 10 t...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-(acetylamino)-N-(1,1-dimethylethyl)-benzamide

Correlated keywords:

210475-67-5 CPI-1189 antiinflammatory neuro-protective IL1? TNF?

Product Overview:
CPI-1189 is a benzamide with neuroprotective and anti-inflammatory activities.{45675,45676,45677,45678,45679} It inhibits phosphorylation of p38 MAPK in IL-1β-stimulated primary rat astrocytes by 70 to 80% when used at concentrations ranging from 10 to 300 nM.{45675} CPI-1189 (20 mg/kg per day) reduces TNF-α-induced apoptosis in the corpus callosum and septum, but not in the neocortex or basal ganglia, as well as reduces TNF-α-induced decreases in GFAP levels in isolated rat brain slices.{45676} It decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, induced by TNF-α in a rat model of AIDS dementia when administered at a dose of 20 mg/kg per day.{45677} CPI-1189 (30 mg/kg per day) reduces crypt loss and decreases the number of ulcers and inflammatory cells in colonic lesions in mouse models of colitis induced by TNBS or dextran sulfate sodium (DSS; Item No. 23250).{45678,45679}

Size	25 mg
Shipping	dry ice
CAS Number	183619-38-7
Molecular Formula	C₁₃H₁₈N₂O₂
SMILES	CC(NC1=CC=C(C(NC(C)(C)C)=O)C=C1)=O
Molecular Weight	234,3
Formulation	A solid
Purity	≥98%
Custom Code	2924.29
UNSPSC code	12352100

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.