(?)-Triptonide

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(?)-Triptonide

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Cat No: 29156

Biochemicals - Natural Products

(–)-Triptonide is a diterpenoid that has been found in T. wilfordii and has diverse biological activities, including immunosuppressant and anticancer properties.{52152,52153} It inhibits IL-2 production and DNA synthesis in phytohemagglutinin-stimulat...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione

Correlated keywords:

Tripterygium immuno suppressant anti cancer IL2 phyto hemagglutinin PC-3 DU-145 Triptonid PG 492 PG492 NSC165677

Product Overview:
(–)-Triptonide is a diterpenoid that has been found in T. wilfordii and has diverse biological activities, including immunosuppressant and anticancer properties.{52152,52153} It inhibits IL-2 production and DNA synthesis in phytohemagglutinin-stimulated T cells (EC50s = 2.46 and 3.2 ng/ml, respectively).{52152} (–)-Triptonide inhibits the proliferation of PC3, DU145, and LNCaP cells (IC50s = 11.96, 10.26, 12.01 nM, respectively).{52153} It induces cell cycle arrest at the G2/M phase and increases apoptosis in PC3 cells in a concentration-dependent manner. (–)-Triptonide (10 mg/kg per day) reduces tumor growth in a PC3 mouse xenograft model.

Size	1 mg
Shipping	dry ice
CAS Number	38647-11-9
Molecular Formula	C₂₀H₂₂O₆
SMILES	O=C1OCC2=C1CC[C@@]3(C)[C@@]2([H])C[C@@]4([H])[C@]5(O4)[C@@]3(O6)[C@]6([H])[C@@](O7)([H])[C@@]7(C(C)C)C5=O
Molecular Weight	358,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.20
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.