Quazinone

Quazinone

CAT N°: 29151
Price:

From 109.00 92.65

Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.{45607,45608} It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 ?M).{45607} Quazinone (10-300 ?g/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.{45608} It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.{45609}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3R)-6-chloro-1,5-dihydro-3-methyl-imidazo[2,1-b]quinazolin-2(3H)-one
  • Correlated keywords
    • 136438/006 Ro136438 Ro13 136438006 6438006 136438 PDE-3 PDGFBB pre-contracted
  • Product Overview:
    Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.{45607,45608} It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 ?M).{45607} Quazinone (10-300 ?g/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.{45608} It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.{45609}

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