Methylcobalamin

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Methylcobalamin

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Cat No: 29113

Biochemicals - Natural Products

Methylcobalamin is an analog of vitamin B12 (Item No. 18425) with diverse neurological activities.{52229,52230,52231,52232} It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activat...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

co-methyl-cobinamide, dihydrogen phosphate (ester), inner salt, 3?-ester with (5,6-dimethyl-1-?-D-ribofuranosyl-1H-benzimidazole-?N3)

Correlated keywords:

35-09-6 13870-88-7 15417-95-5 15550-62-6 19709-17-2 23319-80-4 133191-56-7 B 12 out growth cerebellum ERK1 ERK2 ERK 1 2 hyper algesia neuro pathic fore limb musculo cutaneous amyo trophic Hitocobamin M Methycobal cobalamine Methylcobaz

Product Overview:
Methylcobalamin is an analog of vitamin B12 (Item No. 18425) with diverse neurological activities.{52229,52230,52231,52232} It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 µM.{52229} Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine (Item No. 11764) in a rat model of neuropathic pain.{52230} Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS).{52231} It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.{52232}

Size	100 mg
Shipping	dry ice
CAS Number	13422-55-4
Molecular Formula	C₆₃H₉₁CoN₁₃O₁₄P
SMILES	[CH3-][Co+3]123([N]4=CN([C@@H](O[C@H](CO)[C@H]5O[P]6([O-])=O)[C@]5([H])O)C7=C4C=C(C)C(C)=C7)[N]8=C9[C@@H](CCC(N)=O)[C@@](CC(N)=O)(C)[C@]8(C)[C@@]([C@H](CC(N)=O)[C@]%10(CCC(NC[C@@H](C)O6)=O)C)([H])[N-]1C%10=C(C)C([C@@H](CCC(N)=O)C%11(C)C)=[N]2C%11=CC%12=[N
Molecular Weight	1344,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2936.26
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.